Riluzole Attenuates L-DOPA-Induced Abnormal Involuntary Movements Through Decreasing CREB1 Activity: Insights from a Rat Model.

Mol Neurobiol · 2019 · PMC6647536 · PMID 30484112

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highly significantp value = 2.2E−16actually significant

In addition, CREB1 is the top upstream regulator of the 465 overlapping differentially expressed genes (see previous texts) and there is a highly significant, negative correlation ( r = − 0.91, p value = 2.2E−16) between the fold changes for these genes—including the 58 direct CREB1 target genes—in the two comparisons (Supplementary Fig. 3 ).

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