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Association of US Medical Marijuana Laws With Nonmedical Prescription Opioid Use and Prescription Opioid Use Disorder.

JAMA Netw Open · 2019 · PMC6647549 · PMID 31314118

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a decreasing trendno p-value reported
An ecological study 19 using aggregate data from the 2002 to 2012 National Survey on Drug Use and Health (NSDUH) found a slight inverse association between MML status and state-level aggregate prevalence of NMUPO and a decreasing trend in treatment admissions for OUD after states’ enactment of MMLs with dispensaries.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.