In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs.

Nucleic Acids Res · 2019 · PMC6648356 · PMID 31053845

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closest p · 0.0× alpha

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highly significantP -value < 2.2e–16actually significant

Notably, while the in vitro and the denatured control samples slightly but significantly anticorrelated (average PCC = −0.07, Edgington-combined FDR-adjusted P -value = 3.3e–6), a moderate yet highly significant correlation was instead detected between the in vivo and the denatured control samples (average PCC = 0.18, Edgington-combined FDR-adjusted P -value < 2.2e–16).

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