Among the genes that were upregulated or downregulated in response to Alu overexpression in IMR90, but not in HeLa cells, we found a highly significant enrichment of pathways involved in cell cycle progression and mitotic entry.
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<i>Alu</i> RNA Modulates the Expression of Cell Cycle Genes in Human Fibroblasts.
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The sentences
Compared to the total number of protein-coding genes, this effect was barely significant in the case of AluSx , while it was significant at the Fisher exact test for AluSq2 -overexpressing IMR90 cells.