Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants.

There may be an increasing trend in misspecification with PMA as determined by AFE ( Figure 3 ), as the majority of data used in model development came from preterm infants in the prophylaxis study with a PMA < 35 weeks.

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