Mutations in <i>TFAP2B</i> and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis.

Proc Natl Acad Sci U S A · 2019 · PMC6660739 · PMID 31292255

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP = 8.2 × 10 −12actually significant

Four probands had rare damaging mutations (2 de novo) in TFAP2B , a transcription factor that orchestrates neural crest cell migration and differentiation; this mutation burden is highly significant ( P = 8.2 × 10 −12 ).

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.