The effects of erythromycin, clarithromycin, and telithromycin on simvastatin exposure were variable and highly significant, however the comparison between them was inappropriate as one of them was a single dose study while the other two studies followed a multiple dose approach. 48 – 51 In relation to atorvastatin, the increase in AUC after the administration of macrolides was dose-dependent.
← all excerpts
The clinical significance of statins-macrolides interaction: comprehensive review of in vivo studies, case reports, and population studies.
1
—
—