Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia.

Intest Res · 2019 · PMC6667368 · PMID 31146509

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may not be significantno p-value reported

Confirmation of active inflammation is indicative of pharmacodynamic failure, suggestive that non-TNF driven inflammatory pathways may predominate and there may not be significant benefit from anti-TNF dose escalation or switching to another anti-TNF agent.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.