Minireview: The Epigenetic Modulation of <i>KISS1</i> in Reproduction and Cancer.

Int J Environ Res Public Health · 2019 · PMC6679060 · PMID 31336647

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The epigenetic modulation of Kiss1 or Kiss1r genes within the hypothalamus at puberty onset has been investigated in females, providing evidence that the methylation of both Kiss1 and Kiss1r genes promotes changes across puberty [ 41 ], with the development of highly significant puberty-specific differential promoter methylation patterns.

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