In combination, the seven Nef activities significantly correlated with the model, although only CD4 down-modulation, followed by CXCR4/CCR5 down-modulation (at borderline significance), correlated individually, and CD4 down-modulation capacity contributed the most to the correlation in the multiple linear regression.
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Modelling and <i>in vitro</i> testing of the HIV-1 Nef fitness landscape.
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