Hippocampal long-term potentiation that is elicited by perforant path stimulation or that occurs in conjunction with spatial learning is tightly controlled by beta-adrenoreceptors and the locus coeruleus.

Hippocampus · 2015 · PMC6680149 · PMID 25727388

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highly significantP < 0.001actually significant

Persistent LTP (>25 h) induced by HFS (200 Hz) was highly significant compared with rats that received pp test‐pulse stimulation only (Figs. 4 A,B,D) (PS: F (1,10) = 22.5, P < 0.001; fEPSP: F (1,10) = 26.6, P < 0.001; both groups n = 6).

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