As expected, a highly significant increase in cAMP levels could be observed in untransduced and control-vector transduced Jurkat T-cells, while PDE4A-expressing Jurkat cells showed only a slight increase in cAMP ( Figure 1C ).
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Overexpression of PDE4A Acts as Checkpoint Inhibitor Against cAMP-Mediated Immunosuppression <i>in vitro</i>.
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