Evaluation of SEPP1 and Selenoprotein S Gene Polymorphisms (rs7579 and rs34713741) in Relation to Colorectal Cancer Susceptibility in Subset of Iranian Population: A Case-control Study.

This SNP was significantly associated with advanced adenoma risk in the US population.[ 36 ] A European case–control cohorts, results showed an increased incidence for prostate and CRC in minor alleles (AA) carriers of in SEPP1 rs7579 genotype.[ 26 ] A similar borderline significant result was seen in US physicians for imputed rs7579; the rare allele was associated with increased prostate cancer risk,[ 37 ] but the results showed that this SNP is not associated with CRC in the Korean population and breast cancer incidence in the Danish population.[ 12 , 38 ] The results from different previous studies highlight the key role of selenoproteins and Se in colorectal function and in preventing the cells from undergoing malignant transformation.

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