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Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application.

Front Immunol · 2019 · PMC6685059 · PMID 31417542

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an interesting trendno p-value reported
In the clinical sample evaluated ( 130 ), the majority of GvHD patients were treated with freeze-thawed MSCs with a small number of fresh culture-derived MSCs being available for comparison; while the study lacked sufficient power and thus should be considered with caution, as also emphasized in the discussion, the authors noted an interesting trend of improved clinical outcomes with fresh MSCs, especially those delivered at early passage, in comparison to freeze-thawed MSCs ( 130 , 136 ).

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