Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.

ChemMedChem · 2019 · PMC6686156 · PMID 30664325

Europe PMC DOI

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highly significantp <0.01actually significant

We found that both compounds rapidly decrease the ATP content, with even 30 min inducing a highly significant reduction in cellular ATP levels ( p <0.01), stabilizing at approximately 50 % of untreated [ATP] after 4–6 h ( p <0.001).

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