Identification of a novel functional miR-143-5p recognition element in the Cystic Fibrosis Transmembrane Conductance Regulator 3'UTR.

We observed an increasing trend for miR-143-5p expression in all cell lines following treatment with CF BAL fluid ( Supplementary Figure S2 ), and overall the fold-increase was 3.3 ( Figure 1B ). 3.2. miR-143-5p mediates repression of the CFTR 3′UTR via one binding site In order to assess the ability of miR-143-5p to regulate CFTR expression, we employed publically available software to identify putative MREs in the CFTR 3′UTR.

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