an increasing trendP < 0 05
In the control group, the detection rate of multi-drug-resistant bacteria increased during 2013 to 2015 and then decreased year by year after reaching the peak in 2015 (P < 0.05).Most of the gram-negative bacteria were only susceptible to β-lactam,carbapenems and aminoglycosides with relatively low resistance rates, But the resistance rates showed an increasing trend (P < 0 05).Especially, the drug resistance of Klebsiella pneumoniae was serious (P < 0.05).