Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.

Diabetes · 2019 · PMC6692811 · PMID 31127057

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP = 8.83 * 10 −17actually significant

The respective amino acid sequence (ERKA) was found to be highly significant and positively associated with IA-2A positivity (OR 2.15, P = 8.83 * 10 −17 ).

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extremely significantno p-value reported

Furthermore, some exceptionally small P values are approximated from Gaussian normal distribution and could best be interpreted qualitatively as extremely significant.

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