Considering the patients subdivided in the 3 cohorts, a slight downward trend for all functional indices (HAQ, BASFI, BASG1, BASG2, VAS pain, VAS night pain, and VAS disease activity) and disease activity indices (BASDAI, ASDAS) was observed, which in some cases was statistically significant (see Tables 5 , 6 ), but there was no more markedly significant decrease of these indices in one cohort compared to the other two.
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Serological Biomarkers in Early Axial Spondyloarthritis During 24-Months Follow Up (Italian Arm of Space Study).
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