Extracellular endonucleases in the midgut of Myzus persicae may limit the efficacy of orally delivered RNAi.

While insect numbers on the Mp_C002_dsRNA plants did not differ significantly from that on the empty vector control plants in either generation, the BestBet plants did show a reduction in aphid numbers at a marginal significance level in the second generation (p = 0.025; Fig. 3b ).

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