Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases.

Here, the images obtained by scanning confocal microscopy showed a highly significant co-localization between exogenous cytosolic TDP-43 inclusions and ubiquitin (~85%) in N2A neuroblastoma cells, with respect to cells transfected with control IBs ( Figure 1 D).

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