Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.

In our recently published work we have demonstrated that although farnesylation of UCH-L1 is definitely significant for targeting of LMP1 (and likely some other membrane-associated cargo molecules) to exosomes [ 37 ], blocking UCH-L1 DUB activity with the expression of UCH-L1 DUB-dead mutant somewhat reduces cargo loading to the exosomes as well ([ 37 ] and Figure 1 ).

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