A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.

Eur J Clin Pharmacol · 2019 · PMC6697721 · PMID 31172248

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marginally significantno p-value reported

During the initial screening of the covariates with the empirical Bayes estimates of the basic model, CYP3A5*3 showed a marginally significant effect on the conversion of SV to DHSV (formation parameter for DHSV); however, this effect was not evident once age was considered as a covariate.

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