Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas.

We observed a lesser, but still highly significant, overlap between H3K27me3 marked loci and gene body methylation in CIMP-L1 (13.1%; P = 6.11 × 10 -122 ) and CIMP-L2 (8.5%; P = 1.6 × 10 -78 ) cancers, but did not observe any correlation in CIMP-neg cancers, which likely is owing to the scarcity of which gene body methylation occurs in these cancers.

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There was a nonsignificant trend ( P = .06) for increased ASH1L mutation in CIMP-L1 cancers (13.2%) vs CIMP-L2 cancers (4.9%).

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