Presenilin 1 Regulates [Ca²⁺]i and Mitochondria/ER Interaction in Cultured Rat Hippocampal Neurons.

This yielded a highly significant difference between the PS1 and mPS1 groups, both in the mean magnitude of events (15.5 ± 0.9 pA compared to 13.6 ± 0.6 pA in the PS1 group, p < 0.05) and in the rate of mEPSCs (88 ± 9.3 events per 20 seconds of recording compared to 44.3 ± 6.4 events in the PS1 group, p < 0.001, Figure 2(c) ).

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