Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.

Here, we found that sAPPα (1 nM, 2 h) induced a highly significant increase in newly synthesized Arc protein in both the dendrites (2.72 ± 0.41, p ≤ 0.0001; Figures 3C–E ) and somata (1.69 ± 0.32, p = 0.03) of cultured hippocampal neurons.

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