Barely Significant
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Human metallo-β-lactamase enzymes degrade penicillin.

Sci Rep · 2019 · PMC6704141 · PMID 31434986

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highly significantno p-value reported
Monitoring β-lactamase activities in human cells The functionality of human metallo-β-lactamases on β-lactam drugs appears to be a highly significant question since penicillin has been described as being inactive against obligate intracellular bacteria, such as Coxiella spp ., Rickettsia spp ., Anaplasma spp . and Ehrlichia spp . 13 – 15 .

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