Barely Significant
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System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells.

PLoS One · 2019 · PMC6705839 · PMID 31437187

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highly significantno p-value reported
In contrast, FXR-L treatment results in a highly significant up-regulation of the stem cell marker TBX3 gene expression, particularly pronounced at 4h.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.