The Length of the Expressed 3' UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases.

Front Genet · 2019 · PMC6707137 · PMID 31475030

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highly significantno p-value reported

Furthermore, the reported enrichments remained highly significant after the exclusion of these variants, supporting the idea that promoters and enhancers have an independent role in the genetic component of APA regulation.

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marginal significanceno p-value reported

Together with the marginal significance of the enrichment, this result suggests that the alteration of microRNA binding sites is not among the most relevant mechanisms in the genetic determination of 3′ UTR isoform ratios.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.