Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities.

All 17T clones overexpressing ABCB5 mutants have a statistically highly significant increased proliferation rate compared with the WT ABCB5 clone ( Figure 3a ).

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In both A375 (see Supplementary Figure S3a online) and SK-Mel-28 (see Supplementary Figure S3b ) cell lines, there was a slight trend toward increased invasion of the ABCB5 mutant clones, along with a trend toward reduced invasion in WT ABCB5 clones.

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