Opioid prescription patterns in Germany and the global opioid epidemic: Systematic review of available evidence.

PLoS One · 2019 · PMC6713321 · PMID 31461466

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a pronounced trendno p-value reported

Globally, a pronounced trend towards strong opioids—particularly in non-cancer patients—is described [ 13 , 14 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.