Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors.

Nat Commun · 2019 · PMC6718429 · PMID 31477731

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0.0028

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highly significantP = 0.0028actually significant

Detailed analysis of the palmitoylomics results revealed that knockdown of ZDHHC21 provoked a strong (approximately four-fold change plotted in log 2 scale, which correspond to approximately 15 times decrease in the palmitoylation level) and highly significant ( P = 0.0028) decrease of 5-HT1AR palmitoylation in comparison to the scr samples (Fig. 5h ).

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