LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors.

Analysis of genes commonly upregulated or downregulated by 2 or 6 days of GSK-LSD1 revealed highly significant overlap between the two RNA-seq datasets ( Figures S2B and S2C ), with upregulated genes enriched for genes involved in epidermal differentiation, cornification, and keratinization ( Figure S2G ), whereas genes commonly downregulated were enriched for genes contributing to extracellular matrix organization, collagen fibril organization, and heterotypic cell-cell adhesion ( Figure S2H ).

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Even though GRHL1 and GRHL3 were again upregulated, it did not quite reach statistical significance, although several known targets of these epidermal differentiation TFs were significantly increased in gene expression, such as KRT80 , IVL , and DSG1 ( Figure S2N ).

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