Similar to liver Fxr and Shp ( Figure 4 B), the ileum of iPla2β −/− mice fed with MCD showed significant downregulation of Fxr and a decreasing trend for Fgf15 ( Figure 5 B).
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iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation.
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