Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.

In both cases, death receptor signaling, apoptosis signaling, IL-8 signaling molecular mechanism of cancer, and telomere extension by telomerase are the top five CPs, which is highly significant ( P value 2.99E-13–1.53E-08), but their molecules (having most connectivity in the networks) are different, such as Akt, ERK, ERK1/2, EGF2, P38, MAPK, and SRC (family) in IIA siRNA, and TNF, IL2, and IL-10 in IIB siRNA cells ( Figure 5, C and D ).

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