Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions.

Mol Neurobiol · 2019 · PMC6728280 · PMID 30989628

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The analysis revealed a group of highly significant dysregulated pathways (KEGG) in trisomic cells that was shared at both stages of differentiation, e.g. focal adhesion, extracellular matrix (ECM) function and TGF-beta signalling (Enrichr Combined Score > 10; Supplementary Table 4 ).

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