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Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.

Hepatol Int · 2019 · PMC6728300 · PMID 31172417

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a decreasing trendno p-value reported
an increasing trendno p-value reported
HBV infection-induced ACLF as well as HAV/HEV-induced ACLF is now showing a decreasing trend over time, whereas alcohol and herbs, drugs and supplements (HDS)-induced ACLF show an increasing trend.

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