Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements.

Nat Commun · 2019 · PMC6731277 · PMID 31492858

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

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highly significantp = 1.1e−9actually significant

1 ; interestingly, we found that this enrichment for low-specificity sgRNAs was less pronounced but remained highly significant ( p = 1.1e−9, Fisher’s exact test), showing that the signature of off-target effects can be disguised in noisy screens.

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