Prospective multicentre cohort trial on acute appendicitis and microbiota, aetiology and effects of antimicrobial treatment: study protocol for the MAPPAC (Microbiology APPendicitis ACuta) trial.

BMJ Open · 2019 · PMC6731800 · PMID 31494621

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an increasing trendno p-value reported

The lifetime risk of acute appendicitis in males is 8.6% and 6.7% in females 1 with recent meta-analysis showing an increasing trend in appendicitis incidence in the industrialised countries. 2 Based on the epidemiological and clinical data, acute appendicitis can present either as uncomplicated or complicated with the majority of cases being uncomplicated.

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