Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study).

Mol Genet Genomic Med · 2019 · PMC6732283 · PMID 31389205

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highly significantno p-value reported

We found a highly significant relation between these polymorphisms and risk of frailty, as well as with haplotypes ACG and CCG, which are associated with high and low levels of IL10 production (Scarpelli et al., 2006 ; Suárez, Castro, Alonso, Mozo, & Gutiérrez, 2003 ), which may explain the effect of inflammation on the loss of muscle mass, relevant clinical manifestation in the frailty syndrome (Wang & Casolaro, 2014 ).

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