A half doubling dose change in bronchial hyperresponsiveness in a population represents an important difference.

Transl Respir Med · 2013 · PMC6733426 · PMID 27234386

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highly significantno p-value reported

If this was accompanied by an equivalent increase in the population prevalence of moderate and severe asthma, this would be highly significant in public health terms.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.