Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study.

Sci Rep · 2019 · PMC6733799 · PMID 31501497

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highly significantno p-value reported

We showed a highly significant relation between mGluR5 binding potential and excitotoxicity-mediated neurodegeneration, suggesting that at least part of the mGluR5 alterations were due to the necrotic effect of QA on striatal medium spiny neurons.

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