Barely Significant
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Yeast PAF1 complex counters the pol III accumulation and replication stress on the tRNA genes.

Sci Rep · 2019 · PMC6733944 · PMID 31501524

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The sentences

highly significantp = 4.8E-46actually significant
Paf1 exhibited highly significant enrichment around the TAD boundaries (p = 4.8E-46) but not replication origins (Figs 7C and S6B ).

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