Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis.

Analyses according to baseline CD4 values show a significant higher proportions of undetectability in dolutegravir compared to controls in the subgroup of patients with baseline CD4 levels >200 cells/mmc (RD 0.04; 95% CI, 0.01/0.07); in the subgroup of patients with <200 cells/mmc at baseline there was still a higher proportions of undetectability, of borderline significance (RD 0.06; 95% CI, 0.00/0.11; p = 0.05), in dolutegravir compared to controls, ( Table 2 , S6 Fig ).

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