Modeling Structural Constraints on Protein Evolution via Side-Chain Conformational States.

Mol Biol Evol · 2019 · PMC6736381 · PMID 31114882

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These overlap values correlate with the exchangeabilities, with a Spearman’s ρ of 0.29 ( p = 1.7 × 10 − 28 ), indicating that rotamer states exhibit a weak but highly significant preference to interchange with other rotamer states that occupy similar regions of the Ramachandran plot (see Overlap of backbone distributions ).

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