Large-scale integrated analysis of ovarian cancer tumors and cell lines identifies an individualized gene expression signature for predicting response to platinum-based chemotherapy.

Despite a decreasing trend in incidence and mortality rates over the past few years, patients with OvCa still face low 5-year relative survival rates of no more than 50% due to late-stage diagnoses 2 .

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The results of the meta-analysis suggested that 14 of 16 chemotherapy-responsive genes still are significant or marginally significant associated with OS after adjusting for other clinical variables (Fig. 1a ).

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