Pleiotropic Roles of P2X7 in the Central Nervous System.

The physiopathological relevance of these observations is comforted by in vivo studies showing that LPS treatment of lipin-2ko mice induced highly significant increases in IL-1β and IL-18 serum levels compared to WT animals, an observation attributed in part to P2X7 hyperactivity ( Lorden et al., 2017 ).

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