By pooling nine articles that included 619,644 participants, we showed a linear relationship between A1 st OC and BC risk ( P = .21for a non-linear trend), and a borderline significant association of 0.7% increase in the BC rate for every 1.0-year increase in A1 st OC (i.e., RR: 1.007 [CI: 95%: 1.002–1.013] for each 1.0-year increment).
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Effect of age at first use of oral contraceptives on breast cancer risk: An updated meta-analysis.
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