a trend towards significanceP = 0.098
Within the Diarrhea Cohort, there was a trend towards significance for the tacrolimus trough concentration from the median pre-Abx level of 8 ng/mL to the median post-Abx day 15 level of 9.5 ng/mL ( P = 0.098) and a trend towards significance for the tacrolimus C/D from the median pre-Abx ratio of 2.0 to the median post-Abx day 7 ratio of 2.4 ( P = 0.057) ( Figure S1, SDC , http://links.lww.com/TXD/A221 ) (Tables 3 and 4 ).