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Antimicrobial use policy change in pre-weaned dairy calves and its impact on antimicrobial resistance in commensal Escherichia coli: a cross sectional and ecological study.

BMC Microbiol · 2019 · PMC6739941 · PMID 31514734

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a decreasing trendno p-value reported
In all age groups, the intensity of ampicillin and sulfamethoxazole use showed a decreasing trend with a trough around October and increased slightly until January.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.